MUIIBR successfully develops breeding, production, and supply systems of disease model pigs for rare and intractable disorders

Mar. 01, 2018


Meiji University International Institute for Bio-Resource Research (MUIIBR: Hiroshi Nagashima, Professor in the School of Agriculture) has successfully developed breeding, production, and supply systems of disease model pigs for rare and intractable disorders, and recently published a paper on Proceedings of the National Academy of Sciences of the United States of America (PNAS) on January 8th, 2018.

In research studies on rare and intractable disorders, for which therapeutic methods have not yet been established, animals reproducing the disease, i.e., disease model animals are now playing an important role. In recent years, with the heavy use of pigs in medical research, as a large experimental animal with physiological and anatomical similarities to humans, the development of a rare and intractable genetic disorder model in pigs has become an area of active investigation.

Here, we established a method to relieve the symptoms of a pig with a fatal rare and intractable genetic disorder, leading to healthy growth and even with reproductive ability, by inducing its body issues/organs into a chimeric state with normal cells. Since the development of therapeutic methods and drugs is lagging behind for rare and intractable disorders, which have small patient numbers, the advancement of the supply and practical application of disease model pigs is expected to accelerate the relief of patients.

The details of the study are available on the homepage of the Proceedings of the National Academy of Sciences of the United States of America (http://www.pnas.org/).

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