LU Zixuan, a second-year master’s student in the Applied Chemistry Program at Graduate School of Science and Technology (Laboratory of Biomaterial) won the Best Poster Paper Award at Biomaterials International 2023 (held from July 30 to August 3 at Hokkaido University).
The Laboratory of Biomaterials (Professor AIZAWA Mamoru) in the Department of Applied Chemistry of the School of Science and Technology is working on liver regeneration by tissue engineering using hydroxyapatite (HAp), a major inorganic component in living bone. Tissue engineering is a technology that regenerates tissue by combining three elements: cells, growth factors, and scaffold materials. This laboratory works on development of apatite fiber scaffold (AFS) which has excellent biocompatibility as a scaffold material capable of three-dimensional culture, and communication pores through which cells can enter.
The final goal of this research is to construct a bioartificial liver containing blood vessels. In this research, as a preliminary step, two kinds of cells (hepatocytes and vascular endothelial cells) were co-cultured in various proportions on minute HAp ceramics in two dimensions, and cell culture conditions with high liver function and blood vessel formation were clarified. In the future, this research will move to three-dimensional culture using AFS and aim to construct a three-dimensional artificial liver containing blood vessels.
In recognition of the above research results, it was awarded the Best Poster Paper Award (out of 101 applications, 15 were awarded ). Biomaterials International 2023 brought together the international research communities from various scientific fields, including biology, physiology, materials science, physics, chemistry, engineering, and clinical science, to discuss biomaterials technologies and methodologies.
This research was also carried out as one of the research subjects of the research themes contributing to the achievement of SDGs at the Meiji University International Institute for Materials with Life Functions.
Award Name: Best Poster Paper Award
Society Name: Biomaterials International 2023
Presenters: LU Zixuan, ZHENG Yundi, HOSHIDA Ayaka, SUZUKI Kitaru, FUJITA Tatsuo, HONDA Michiyo, MATSUURA Tomokazu, AIZAWA Mamoru
Title: CO-CULTURE OF HepG2 CELLS AND HUVECs USING APATITE CERAMICS FOR CONSTRUCTION OF REGENERATED LIVER ORGANOIDS CONTAINING BLOOD VESSELS
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