[Graduate School of Science and Technology] FUKUDA Ryuichi’s research presentation was selected as a “highlight lecture” of the 45th Annual Meeting of the Japanese Society for Biomaterials
Dec. 07, 2023
A research presentation by FUKUDA Ryuichi (Laboratory of Biomaterials), a first-year master’s student in the Applied Chemistry Program at the Graduate School of Science and Technology, was selected as a “highlight lecture” at the 45th Annual Meeting of the Japanese Society for Biomaterials held on November 6 and 7, 2023.
The Laboratory of Biomaterials (Professor AIZAWA Mamoru), to which Mr. Fukuda belongs, is working on establishing a novel cancer chemoembolization therapy based on a Drug Delivery System (DDS), in which an angiogenesis inhibitor is loaded onto tricalcium phosphate, which has a chemical composition similar to that of biological bone and is absorbed and replaced within the body. In this study, spherical tricalcium phosphate microspheres were fabricated by ultrasonic spray pyrolysis and loaded with an anticancer drug, and their antitumor effects were evaluated in a cancer-bearing mouse model of malignant melanoma (B16-F10 cells) derived from mice. Tumor diameter measurements showed that the groups treated with the anticancer drug-only and anticancer drug-loaded microspheres significantly inhibited tumor growth compared with the control group. In particular, the anticancer drug-loaded microsphere group showed a significant inhibition of tumor growth. In addition, histological evaluation revealed an abundance of M1 macrophages, which are responsible for eliminating many dead cells and cancer cells, near the microspheres in the anticancer drug-loaded microsphere group. These results suggest that the synergistic effects of the microspheres and the anticancer drug were able to better inhibit tumor growth.
The above research was highly evaluated and selected as one of the 38 “highlight lectures” from about 400 research presentations at this year’s meeting.
https://lynx-dent.jp/jsb45/wp-content/uploads/2023/10/highlight_lecture.pdf
Note that the Japanese Society for Biomaterials, specializing in biomaterials, is the only society of its kind in Japan, and this meeting marks its 45th iteration.
Furthermore, this research was conducted in collaboration with Professor NAGAI Shigenori, an immunology expert at Tokyo Medical and Dental University, as part of the Meiji University International Institute for Materials with Life Functions.
Name of society: The 45th Annual Meeting of the Japanese Society for Biomaterials
Venue: Kobe (Kobe International Conference Center)
Date: November 6-7, 2023 (Presentation date: November 6, 2023)
Presenters: FUKUDA Ryuichi, ZHENG Yundi, NOSE Masato, OSHIMA Yuki, NAGAI Shigenori, AIZAWA Mamoru
Theme: Preparation of calcium phosphate loaded with anticancer drugs and verification of antitumor effects using tumor-bearing mice
≪Japanese version≫
The Laboratory of Biomaterials (Professor AIZAWA Mamoru), to which Mr. Fukuda belongs, is working on establishing a novel cancer chemoembolization therapy based on a Drug Delivery System (DDS), in which an angiogenesis inhibitor is loaded onto tricalcium phosphate, which has a chemical composition similar to that of biological bone and is absorbed and replaced within the body. In this study, spherical tricalcium phosphate microspheres were fabricated by ultrasonic spray pyrolysis and loaded with an anticancer drug, and their antitumor effects were evaluated in a cancer-bearing mouse model of malignant melanoma (B16-F10 cells) derived from mice. Tumor diameter measurements showed that the groups treated with the anticancer drug-only and anticancer drug-loaded microspheres significantly inhibited tumor growth compared with the control group. In particular, the anticancer drug-loaded microsphere group showed a significant inhibition of tumor growth. In addition, histological evaluation revealed an abundance of M1 macrophages, which are responsible for eliminating many dead cells and cancer cells, near the microspheres in the anticancer drug-loaded microsphere group. These results suggest that the synergistic effects of the microspheres and the anticancer drug were able to better inhibit tumor growth.
The above research was highly evaluated and selected as one of the 38 “highlight lectures” from about 400 research presentations at this year’s meeting.
https://lynx-dent.jp/jsb45/wp-content/uploads/2023/10/highlight_lecture.pdf
Note that the Japanese Society for Biomaterials, specializing in biomaterials, is the only society of its kind in Japan, and this meeting marks its 45th iteration.
Furthermore, this research was conducted in collaboration with Professor NAGAI Shigenori, an immunology expert at Tokyo Medical and Dental University, as part of the Meiji University International Institute for Materials with Life Functions.
Name of society: The 45th Annual Meeting of the Japanese Society for Biomaterials
Venue: Kobe (Kobe International Conference Center)
Date: November 6-7, 2023 (Presentation date: November 6, 2023)
Presenters: FUKUDA Ryuichi, ZHENG Yundi, NOSE Masato, OSHIMA Yuki, NAGAI Shigenori, AIZAWA Mamoru
Theme: Preparation of calcium phosphate loaded with anticancer drugs and verification of antitumor effects using tumor-bearing mice
≪Japanese version≫
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